Regular strength: 325-650 mg PO/PR q4hr PRN; not to exceed 3250 mg/day; under supervision of healthcare professional, daily doses of up to 4 g/day may be used
Extra Strength: 1000 mg PO q6-8hr PRN; not to exceed 3000 mg/day; under supervision of healthcare professional, daily doses of up to 4 g/day may be used:
extended-release
2 capsules (1300 mg) PO q8hr PRN; not to exceed 3.9 g/day
maximum dose
Acetaminophen containing products: Not to exceed a cumulative dose of 3.25 g/day of acetaminophen; under supervision of healthcare professional, daily doses of up to 4 g/day may be used
Tylenol Extra-Strength (ie, 500 mg/tab or cap): Not to exceed 3 g/day (6 tabs or caps); under supervision of healthcare professional, daily doses of up to 4 g/day may be used
Dosing Considerations
When calculating the maximum daily dose, consider all sources of acetaminophen, including OTC, and routes of administration not to exceed the maximum recommended daily dosing
Renal Impairment
GFR≥50 mL/min: No dosage adjustment necessary
GFR 10-50 mL/min: Administer q6hr
GFR<10mL/min: Administer q8hr
Continuous renal replacement therapy: Administer q6hr
Hepatic Impairment
Use extreme caution; avoid use as much as possible; limit therapy to short-term use at doses not to exceed 2 g/day
