Rheumatology18 Videos

Psoriasis vulgaris – Ursachen, Symptome und Behandlung – dermanostic Hautlexikon

Pathophysiology of plaque psoriasis   ●Psoriasis is a complex immune-mediated disorder that presents as inflammatory plaques in the skin. Dysregulation or alteration of components of the innate and adaptive immune systems, keratinocyte function, and vascular structure contribute to the manifestations of this disease. ●Plasmacytoid and myeloid dendritic cells are key contributors to development of inflammation […]

Psoriasis- Signs, Symptoms, Causes, and Treatment

Clinical presentation •Variants The major clinical forms of psoriasis are similar in children and adults. Chronic plaque psoriasis is the most common form of psoriasis in children. Guttate, pustular, and erythrodermic psoriasis are less frequent.  Chronic plaque psoriasis is characterized by the presence of well-demarcated, erythematous plaques with silvery-white, mica-like scale. In children with highly […]

What Happens During a Gout Attack

Clinical manifestations and diagnosis of gout Natural history and role of hyperuricemia The three clinical stages in the natural history of progressive urate crystal deposition disease (gout) are the gout flare, intercritical (or interval) gout, and chronic gouty arthritis and tophaceous gout. Use of effective urate-lowering therapies has resulted in a reduced frequency of progression […]

Gout- Everything You Need to Know

Clinical manifestations and diagnosis of gout Natural history and role of hyperuricemia The three clinical stages in the natural history of progressive urate crystal deposition disease (gout) are the gout flare, intercritical (or interval) gout, and chronic gouty arthritis and tophaceous gout. Use of effective urate-lowering therapies has resulted in a reduced frequency of progression […]

Gout

INTRODUCTION Gout (monosodium urate [MSU] crystal deposition disease) is characterized biochemically by extracellular fluid urate saturation, which is reflected in the blood by hyperuricemia, with serum or plasma urate concentrations exceeding 6.8 mg/dL (approximately 400 micromol/L); this level of urate is the approximate limit of urate solubile The clinical manifestations of gout may include: ●Recurrent […]

Gout

TREATMENT OF COMORBIDITIES Weight reduction towards ideal body weight and moderation in ethanol consumption have each been convincingly shown to reduce both the risk of incident gout and the expression of established gout. Other comorbidities have also been the subject of study. Hyperuricemia and gout are frequently accompanied by one or more major disorders, such as […]

Gout – causes, symptoms, diagnosis, treatment, pathology

LABORATORY FINDINGS Synovial fluid analysis  The gout flare is characterized by the presence of monosodium urate (MSU) crystals in synovial fluid obtained from joints or bursas visualized by direct examination of a sample of fluid using compensated polarized light microscop. Urate crystals may also be identified frequently by this technique in material aspirated during the […]