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Gout1
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Gout

INTRODUCTION Gout (monosodium urate [MSU] crystal deposition disease) is characterized biochemically by extracellular fluid urate saturation, which is reflected in the blood by hyperuricemia, with serum or plasma urate concentrations exceeding 6.8 mg/dL (approximately 400 micromol/L); this level of urate is the approximate limit of urate solubile The clinical manifestations of gout may include: ●Recurrent […]
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Gout – causes, symptoms, diagnosis, treatment, pathology
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Gout – causes, symptoms, diagnosis, treatment, pathology

LABORATORY FINDINGS Synovial fluid analysis  The gout flare is characterized by the presence of monosodium urate (MSU) crystals in synovial fluid obtained from joints or bursas visualized by direct examination of a sample of fluid using compensated polarized light microscop. Urate crystals may also be identified frequently by this technique in material aspirated during the […]
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Gout- Everything You Need to Know

Clinical manifestations and diagnosis of gout Natural history and role of hyperuricemia The three clinical stages in the natural history of progressive urate crystal deposition disease (gout) are the gout flare, intercritical (or interval) gout, and chronic gouty arthritis and tophaceous gout. Use of effective urate-lowering therapies has resulted in a reduced frequency of progression […]
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Psoriasis vulgaris – Ursachen, Symptome und Behandlung – dermanostic Hautlexikon
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Psoriasis vulgaris – Ursachen, Symptome und Behandlung – dermanostic Hautlexikon

Pathophysiology of plaque psoriasis ●Psoriasis is a complex immune-mediated disorder that presents as inflammatory plaques in the skin. Dysregulation or alteration of components of the innate and adaptive immune systems, keratinocyte function, and vascular structure contribute to the manifestations of this disease. ●Plasmacytoid and myeloid dendritic cells are key contributors to development of inflammation in […]
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